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Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic beta-cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00518635" target="_blank" >RIV/67985823:_____/19:00518635 - isvavai.cz</a>

  • Result on the web

    <a href="https://doi.org/10.1016/j.mito.2019.06.007" target="_blank" >https://doi.org/10.1016/j.mito.2019.06.007</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1016/j.mito.2019.06.007" target="_blank" >10.1016/j.mito.2019.06.007</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic beta-cells

  • Original language description

    Type 2 diabetes progression stems from dysfunction of beta-cells, besides the peripheral insulin resistance. Mitochondria as glucose sensor and regulation center are impaired at various stages of this progression. Their biogenesis and functional impairment is reflected by altered morphology of the mitochondrial network and ultramorphology of cristae and mitochondrial DNA loci, termed nucleoids. Aspects of all above changes are reviewed here together with a brief introduction to proteins involved in mitochondrial network dynamics, cristae shaping, and mtDNA nucleoid structure and maintenance. Most frequently, pathology is reflected by the fragmentation of network, cristae inflation or absence and declining number of nucleoids.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30202 - Endocrinology and metabolism (including diabetes, hormones)

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Mitochondrion

  • ISSN

    1567-7249

  • e-ISSN

  • Volume of the periodical

    49

  • Issue of the periodical within the volume

    Nov

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    14

  • Pages from-to

    245-258

  • UT code for WoS article

    000503545000028

  • EID of the result in the Scopus database

    2-s2.0-85068364638