Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic beta-cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F67985823%3A_____%2F19%3A00518635" target="_blank" >RIV/67985823:_____/19:00518635 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1016/j.mito.2019.06.007" target="_blank" >https://doi.org/10.1016/j.mito.2019.06.007</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.mito.2019.06.007" target="_blank" >10.1016/j.mito.2019.06.007</a>
Alternative languages
Result language
angličtina
Original language name
Dynamic of mitochondrial network, cristae, and mitochondrial nucleoids in pancreatic beta-cells
Original language description
Type 2 diabetes progression stems from dysfunction of beta-cells, besides the peripheral insulin resistance. Mitochondria as glucose sensor and regulation center are impaired at various stages of this progression. Their biogenesis and functional impairment is reflected by altered morphology of the mitochondrial network and ultramorphology of cristae and mitochondrial DNA loci, termed nucleoids. Aspects of all above changes are reviewed here together with a brief introduction to proteins involved in mitochondrial network dynamics, cristae shaping, and mtDNA nucleoid structure and maintenance. Most frequently, pathology is reflected by the fragmentation of network, cristae inflation or absence and declining number of nucleoids.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30202 - Endocrinology and metabolism (including diabetes, hormones)
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Mitochondrion
ISSN
1567-7249
e-ISSN
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Volume of the periodical
49
Issue of the periodical within the volume
Nov
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
14
Pages from-to
245-258
UT code for WoS article
000503545000028
EID of the result in the Scopus database
2-s2.0-85068364638