Alteration of the HSP70/HSP90 chaperone and the HOP/CHIP co-chaperone system in cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000328" target="_blank" >RIV/00209805:_____/12:#0000328 - isvavai.cz</a>

Result on the web

<a href="http://www.springerlink.com/content/j27772813123n887/" target="_blank" >http://www.springerlink.com/content/j27772813123n887/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2478/s11658-012-0021-8" target="_blank" >10.2478/s11658-012-0021-8</a>

Result language

angličtina

Original language name

Alteration of the HSP70/HSP90 chaperone and the HOP/CHIP co-chaperone system in cancer

Original language description

Activation of the Hsp90 chaperone system is a characteristic of cancer cells. The regulation of chaperone activities involves their interaction with cochaperones; therefore we investigated the expression of Hsp70 and Hsp90 and their specific co-chaperones HOP and CHIP in cancer cell lines and primary cancers. Inhibition of Hsp90 by 17AAG increased the levels of Hsp70, Hsp90 and HOP but not CHIP mRNA in cancer cells. These changes are linked to activation of the HSF1 transcription factor and we show thatthe HOP promoter contains HSF1 binding sites, and that HSF1 binding to the HOP promoter is increased following 17AAG. The lack of alteration in the co-chaperone CHIP is explained by a lack of HSF response elements in the CHIP promoter. Nonproliferatingcells expressed higher levels of CHIP and lower HOP, Hsp70 and Hsp90 levels compared to proliferating cells. Decreased expression of CHIP in proliferating cancer cells is in keeping with its proposed tumor suppressor properties, while ove

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

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Project

<a href="/en/project/NS9812" target="_blank" >NS9812: Elucidating the role of ubiquitin-chaperone degradation machinery in cancer and modulating its biochemical functions using targeted chaperone inhibitors</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cellular and molecular biology letters

ISSN

1425-8153

e-ISSN

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Volume of the periodical

17

Issue of the periodical within the volume

3

Country of publishing house

PL - POLAND

Number of pages

13

Pages from-to

446-458

UT code for WoS article

000305349300009

EID of the result in the Scopus database

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