The Assembly and Intermolecular Properties of the Hsp70-Tomm34-Hsp90 Molecular Chaperone Complex*

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F14%3A10286928" target="_blank" >RIV/00216208:11310/14:10286928 - isvavai.cz</a>
Alternative codes found
RIV/61388971:_____/14:00440365 RIV/00209805:_____/14:#0000511
Result on the web
<a href="http://dx.doi.org/10.1074/jbc.M113.526046" target="_blank" >http://dx.doi.org/10.1074/jbc.M113.526046</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1074/jbc.M113.526046" target="_blank" >10.1074/jbc.M113.526046</a>

Result language
angličtina
Original language name
The Assembly and Intermolecular Properties of the Hsp70-Tomm34-Hsp90 Molecular Chaperone Complex*
Original language description
Background: Hsp70 and Hsp90 molecular chaperones associate with the network of co-chaperone proteins. Results: Tomm34 protein interacts with both Hsp70 and Hsp90 chaperones. Conclusion: Tomm34 scaffolds Hsp70/Hsp90 chaperones by their simultaneous binding. Significance: Tomm34 represents a novel Hsp70/Hsp90 co-chaperone. Maintenance of protein homeostasis by molecular chaperones Hsp70 and Hsp90 requires their spatial and functional coordination. The cooperation of Hsp70 and Hsp90 is influenced by theirinteraction with the network of co-chaperone proteins, some of which contain tetratricopeptide repeat (TPR) domains. Critical to these interactions are TPR domains that target co-chaperone binding to the EEVD-COOH motif that terminates Hsp70/Hsp90. Recently, the two-TPR domain-containing protein, Tomm34, was reported to bind both Hsp70 and Hsp90. Here we characterize the structural basis of Tomm34-Hsp70/Hsp90 interactions. Using multiple methods, including pull-down assays, fluorescence
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EE - Microbiology, virology
OECD FORD branch
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Project
<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2014
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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