Hypoxia and p53
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000331" target="_blank" >RIV/00209805:_____/12:#0000331 - isvavai.cz</a>
Result on the web
<a href="http://www.peterlang.com/index.cfm?cid=165#5500758" target="_blank" >http://www.peterlang.com/index.cfm?cid=165#5500758</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Hypoxia and p53
Original language description
The TP53 gene has a major role as an intgerator of cellular stresses and is commnly mutated or inactivated in human cancers. As well as inducing growth arrest and cell death by transcriptional activation of target genes after genotoxic stress, p53 also responds to hypoxia. Under hypoxic conditions, p53 acts largely as a transcriptional repressor but also enhancer HUF-1-mediated activation of apoptosis. Mutation to TP53 in tumours allows increased survival in hypoxia, suggesting that these pathways couldbe therapeutically useful. The two other members of the p53-family, p63 and p73, also influence hypoxic responses in poorly defined ways.
Czech name
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Czech description
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Classification
Type
C - Chapter in a specialist book
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Book/collection name
Tumour hypoxia: molecular mechanism and clinical implications
ISBN
978-3-631-63991-7
Number of pages of the result
24
Pages from-to
235-258
Number of pages of the book
556
Publisher name
Peter Lang
Place of publication
Frankfurt am Main
UT code for WoS chapter
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