Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62156489%3A43210%2F20%3A43917973" target="_blank" >RIV/62156489:43210/20:43917973 - isvavai.cz</a>
Alternative codes found
RIV/00216305:26620/20:PU136649
Result on the web
<a href="https://doi.org/10.37904/nanocon.2019.8611" target="_blank" >https://doi.org/10.37904/nanocon.2019.8611</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37904/nanocon.2019.8611" target="_blank" >10.37904/nanocon.2019.8611</a>
Alternative languages
Result language
angličtina
Original language name
Gold nanoparticles modified screen printed carbon electrode as a tool for detection of TP53
Original language description
Cancer is one of the most common causes of death in developing countries and in the developed world. The function of the p53 protein plays an important role in the development of cancer. The protein p53 regulates the expression of genes that are responsible for the control of cell growth, apoptosis or for repair of damaged DNA. It t is encoded by the tumor suppressor gene TP53. If this gene mutates, its product will be damaged. It was found that mutations in the TP53 gene is present in more than 50% of cancer cases. Electrochemical biosensors have proved to be a suitable method for the detection of TP53 and also its mutations. Electrochemical deposition of gold nanoparticles on the surface of working electrode increases the active surface area of the sensor, this leads to a more sensitive detection of the TP53 gene and its mutations. By developing an electrochemical biosensor based on gold nanoparticles modified screen printed electrodes, an efficient platform for detecting the TP53 gene in biological samples is obtained.
Czech name
—
Czech description
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Classification
Type
D - Article in proceedings
CEP classification
—
OECD FORD branch
10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)
Result continuities
Project
<a href="/en/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Article name in the collection
NANOCON 2019: Conference Proceedings
ISBN
978-80-87294-95-6
ISSN
2694-930X
e-ISSN
—
Number of pages
4
Pages from-to
402-405
Publisher name
Tanger Ltd.
Place of publication
Ostrava
Event location
Brno
Event date
Oct 16, 2019
Type of event by nationality
WRD - Celosvětová akce
UT code for WoS article
000664115400067