Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023736%3A_____%2F20%3A00013056" target="_blank" >RIV/00023736:_____/20:00013056 - isvavai.cz</a>
Result on the web
<a href="https://doi.org/10.1038/s41591-020-1008-z" target="_blank" >https://doi.org/10.1038/s41591-020-1008-z</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/s41591-020-1008-z" target="_blank" >10.1038/s41591-020-1008-z</a>

Result language
angličtina
Original language name
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Original language description
Tumor protein p53 (TP53) is the most frequently mutated gene in cancer. In patients with myelodysplastic syndromes (MDS), TP53 mutations are associated with high-risk disease, rapid transformation to acute myeloid leukemia (AML), resistance to conventional therapies and dismal outcomes. Consistent with the tumor-suppressive role of TP53, patients harbor both mono- and biallelic mutations. However, the biological and clinical implications of TP53 allelic state have not been fully investigated in MDS or any other cancer type.
Czech name
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Czech description
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Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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