Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in the Czech Republi

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000380" target="_blank" >RIV/00209805:_____/12:#0000380 - isvavai.cz</a>

Result on the web

<a href="http://www.touchoncology.com/articles/initial-experience-determination-hterc-and-mycc-amplification-cervical-intraepithelial-neop" target="_blank" >http://www.touchoncology.com/articles/initial-experience-determination-hterc-and-mycc-amplification-cervical-intraepithelial-neop</a>

DOI - Digital Object Identifier

—

Result language

angličtina

Original language name

Initial experience with determination of hTERC and MYCC amplification in cervical intraepithelial neoplasia and cervical carcinoma in the Czech Republi

Original language description

Tumours are frequently characterised by series of cytogenetic abnormalities. Amplifications of the human telomerase gene hTERC (3q26) and myelocytomatosis-C proto-oncogene MYCC (8q24) have been associated with cervical intraepithelial neoplasia (CIN) andcarcinoma of the uterine cervix. The results of genetic analysis allow to select patients at high risk of progression from CIN to carcinoma. Our group conducted a study in which the chromosomal abnormalities found in the cytology specimens of 26 patients with either cervical cancer or CIN were analysed using the recently developed triple-colour human papillomavirus-fluorescence in situ hybridisation (HPV-FISH) assay. HPV infection was proven in 22 (85 %) patients. Amplification of MYCC and hTERC was found in 11 (42 %) and 16 (62 %) patients, respectively. Based on these results, the patients were divided into high-risk, medium-risk and low-risk groups. The study confirmed that the HPV-FISH assay can be used as an effective diagnostic p

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2012

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European oncology and haematology

ISSN

2045-5275

e-ISSN

—

Volume of the periodical

8

Issue of the periodical within the volume

2

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

92-96

UT code for WoS article

—

EID of the result in the Scopus database

—