Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: Evidence against their usage as biomarkers in colorectal cancer

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F12%3A%230000468" target="_blank" >RIV/00209805:_____/12:#0000468 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14740/12:00065584
Result on the web
<a href="http://iospress.metapress.com/content/b357206815144543/?issue=4&genre=article&spage=199&issn=1574-0153&volume=12" target="_blank" >http://iospress.metapress.com/content/b357206815144543/?issue=4&genre=article&spage=199&issn=1574-0153&volume=12</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3233/CBM-130308" target="_blank" >10.3233/CBM-130308</a>

Result language
angličtina
Original language name
Circulating miR-17-3p, miR-29a, miR-92a and miR-135b in serum: Evidence against their usage as biomarkers in colorectal cancer
Original language description
BACKGROUND: Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the world. Therefore, there is a high demand for cost-effective and non-invasive biomarkers that would enable an early detection of asymptomatic and curable disease with high sensitivity and specificity. OBJECTIVE: The main objective of this study was to investigate the potential of circulating miRNAs as biomarkers of CRC. METHODS: Total RNA enriched for small RNAs was isolated from 100 sera of patients with CRCand 30 sera of healthy donors. The expression levels of miR-17-3p, miR-29a, miR-92a and miR-135b were determined using quantitative real-time PCR. The average expression levels of particular miRNAs were normalized to miR-16 levels and statistically evaluated. RESULTS: Using Mann-Whitney U test, no significant differences were observed in miR-17-3p (P = 0.18), miR-29a (P = 0.14) and miR-92a (P = 0.60) levels between sera of CRC patients and controls. The levels of miR-135b in serum were t
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2012
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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