Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F15%3A00452269" target="_blank" >RIV/68378041:_____/15:00452269 - isvavai.cz</a>

Alternative codes found

RIV/00064190:_____/15:#0001058 RIV/00216208:11110/15:10295096

Result on the web

<a href="http://dx.doi.org/10.1186/s12885-015-1327-5" target="_blank" >http://dx.doi.org/10.1186/s12885-015-1327-5</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s12885-015-1327-5" target="_blank" >10.1186/s12885-015-1327-5</a>

Result language

angličtina

Original language name

Circulating miRNAs miR-34a and miR-150 associated with colorectal cancer progression

Original language description

Background: Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and their efficiency at delineatingpatients with polyps and benign adenomas from normal and cancer patient groups. Methods: The expression of 667 miRNAs was assessed in a discovery set of 48 plasma samples comprising normal, polyp, adenoma, and early and advanced cancer samples. Three miRNAs (miR-34a, miR-150, and miR-923) were further examined in a validation cohort of 97 subjects divided into the same five groups, and in an independent public dataset of 40 CRC samples and paired normal tissues. Results: High levels of circulating miR-34a and low miR-150 levels distinguished groups of patients with polyps from those with advanced cancer (AUC = 0.904), and low circulating miR-150 levels separated patients with adenomas from those with advanced cancer (AUC = 0.875). In ad

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

—

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Bmc Cancer

ISSN

1471-2407

e-ISSN

—

Volume of the periodical

15

Issue of the periodical within the volume

apr 30

Country of publishing house

GB - UNITED KINGDOM

Number of pages

13

Pages from-to

2-13

UT code for WoS article

000353771200002

EID of the result in the Scopus database

2-s2.0-84928819020