Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000627" target="_blank" >RIV/00209805:_____/15:#0000627 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.2147/OTT.S82235" target="_blank" >http://dx.doi.org/10.2147/OTT.S82235</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2147/OTT.S82235" target="_blank" >10.2147/OTT.S82235</a>
Alternative languages
Result language
angličtina
Original language name
Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients
Original language description
Anterior gradient protein (AGR) 3 is a highly related homologue of pro-oncogenic AGR2 and belongs to the family of protein disulfide isomerases. Although AGR3 was found in breast, ovary, prostate, and liver cancer, it remains of yet poorly defined function in tumo-rigenesis. This study aimed to determine AGR3 expression in a cohort of 129 primary breast carcinomas and evaluate the clinical and prognostic significance of AGR3 in these tumors. The immunohistochemical analysis revealed the presence of AGR3staining to varying degrees in 80% of analyzed specimens. The percentage of AGR3-positive cells significantly correlated with estrogen receptor, progesterone receptor (both P,0.0001) as well as low histological grade (P=0.003), and inversely correlatedwith the level of Ki-67 expression (P,0.0001). In the whole cohort, AGR3 expression was associated with longer progression-free survival (PFS), whereas AGR3-positive subgroup of low-histological grade tumors showed both significantly long
Czech name
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Czech description
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Classification
Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
FD - Oncology and haematology
OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
OncoTargets and therapy
ISSN
1178-6930
e-ISSN
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Volume of the periodical
8
Issue of the periodical within the volume
June
Country of publishing house
NZ - NEW ZEALAND
Number of pages
10
Pages from-to
1523-1532
UT code for WoS article
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EID of the result in the Scopus database
2-s2.0-84934273566