B-Cell activating factor as a cancer biomarker and its implications in cancer-related cachexia
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000631" target="_blank" >RIV/00209805:_____/15:#0000631 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1155/2015/792187" target="_blank" >http://dx.doi.org/10.1155/2015/792187</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2015/792187" target="_blank" >10.1155/2015/792187</a>
Alternative languages
Result language
angličtina
Original language name
B-Cell activating factor as a cancer biomarker and its implications in cancer-related cachexia
Original language description
B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily.The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFFantibody, belimumab, for the therapy of systemic lupus erythematosus. Concomitantly, the role of BAFF in cancer has been a subject of research since its discovery. Here we review BAFF as a biomarker of malignant disease activity and prognostic factor inB-cell derived malignancies such as multiple myeloma. Moreover, anti-BAFF therapy seems to be a promising approach in treatment of B-cell derived leukemias/lymphomas. In nonhematologic solid tumors, BAFF may contribute to cancer progression by mechanisms both dependent on and independent of BAFF?s proinflammatory role. We also describe ongoing research into the pathophysiological link between BAFF and cancer-related cachexia. BAFF has been shown to contribute to inflammation and insulin
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2015
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
BioMed Research international
ISSN
2314-6141
e-ISSN
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Volume of the periodical
2015
Issue of the periodical within the volume
2015
Country of publishing house
US - UNITED STATES
Number of pages
9
Pages from-to
"article number 792187"
UT code for WoS article
000359550200001
EID of the result in the Scopus database
2-s2.0-84939839788