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B-Cell activating factor as a cancer biomarker and its implications in cancer-related cachexia

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F15%3A%230000631" target="_blank" >RIV/00209805:_____/15:#0000631 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1155/2015/792187" target="_blank" >http://dx.doi.org/10.1155/2015/792187</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1155/2015/792187" target="_blank" >10.1155/2015/792187</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    B-Cell activating factor as a cancer biomarker and its implications in cancer-related cachexia

  • Original language description

    B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily.The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFFantibody, belimumab, for the therapy of systemic lupus erythematosus. Concomitantly, the role of BAFF in cancer has been a subject of research since its discovery. Here we review BAFF as a biomarker of malignant disease activity and prognostic factor inB-cell derived malignancies such as multiple myeloma. Moreover, anti-BAFF therapy seems to be a promising approach in treatment of B-cell derived leukemias/lymphomas. In nonhematologic solid tumors, BAFF may contribute to cancer progression by mechanisms both dependent on and independent of BAFF?s proinflammatory role. We also describe ongoing research into the pathophysiological link between BAFF and cancer-related cachexia. BAFF has been shown to contribute to inflammation and insulin

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    Result was created during the realization of more than one project. More information in the Projects tab.

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2015

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    BioMed Research international

  • ISSN

    2314-6141

  • e-ISSN

  • Volume of the periodical

    2015

  • Issue of the periodical within the volume

    2015

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    9

  • Pages from-to

    "article number 792187"

  • UT code for WoS article

    000359550200001

  • EID of the result in the Scopus database

    2-s2.0-84939839788