B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F15%3A00083140" target="_blank" >RIV/00216224:14110/15:00083140 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/15:00063247

Result on the web

<a href="http://dx.doi.org/10.1155/2015/792187" target="_blank" >http://dx.doi.org/10.1155/2015/792187</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1155/2015/792187" target="_blank" >10.1155/2015/792187</a>

Result language

angličtina

Original language name

B-Cell Activating Factor as a Cancer Biomarker and Its Implications in Cancer-Related Cachexia

Original language description

B-cell activating factor (BAFF) is a cytokine and adipokine of the TNF ligand superfamily. The main biological function of BAFF in maintaining the maturation of B-cells to plasma cells has recently made it a target of the first FDA-approved selective BAFF antibody, belimumab, for the therapy of systemic lupus erythematosus. Concomitantly, the role of BAFF in cancer has been a subject of research since its discovery. Here we review BAFF as a biomarker of malignant disease activity and prognostic factor in B-cell derived malignancies such as multiple myeloma. Moreover, anti-BAFF therapy seems to be a promising approach in treatment of B-cell derived leukemias/lymphomas. In nonhematologic solid tumors, BAFF may contribute to cancer progression by mechanisms both dependent on and independent of BAFF's proinflammatory role. We also describe ongoing research into the pathophysiological link between BAFF and cancer-related cachexia.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EI - Biotechnology and bionics

OECD FORD branch

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Project

<a href="/en/project/LM2011017" target="_blank" >LM2011017: Advanced Cell Immunotherapy Unit - ACIU</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2015

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Biomed Research International

ISSN

2314-6133

e-ISSN

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Volume of the periodical

2015

Issue of the periodical within the volume

"792187"

Country of publishing house

US - UNITED STATES

Number of pages

9

Pages from-to

1-9

UT code for WoS article

000359550200001

EID of the result in the Scopus database

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