No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F16%3AN0000058" target="_blank" >RIV/00209805:_____/16:N0000058 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/18:00101981 RIV/00216208:11110/18:10376223 RIV/00209805:_____/18:00078122

Result on the web

<a href="http://insights.ovid.com/crossref?an=00008469-900000000-99422" target="_blank" >http://insights.ovid.com/crossref?an=00008469-900000000-99422</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/CEJ.0000000000000244" target="_blank" >10.1097/CEJ.0000000000000244</a>

Result language

angličtina

Original language name

No association between global DNA methylation in peripheral blood and lung cancer risk in nonsmoking women: results from a multicenter study in Eastern and Central Europe

Original language description

Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case-control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.

Czech name

—

Czech description

—

Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FD - Oncology and haematology

OECD FORD branch

—

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2016

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

European journal of cancer prevention

ISSN

0959-8278

e-ISSN

—

Volume of the periodical

Neuveden

Issue of the periodical within the volume

April

Country of publishing house

GB - UNITED KINGDOM

Number of pages

5

Pages from-to

nestránkováno

UT code for WoS article

—

EID of the result in the Scopus database

—