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No association between global DNA methylation in peripherial blood and lung cancer risk in nonsmoking women: results from multicenter study in Eastern and Central Europe

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F18%3A73581884" target="_blank" >RIV/61989592:15110/18:73581884 - isvavai.cz</a>

  • Result on the web

    <a href="http://dx.doi.org/10.1097/CEJ.0000000000000244" target="_blank" >http://dx.doi.org/10.1097/CEJ.0000000000000244</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1097/CEJ.0000000000000244" target="_blank" >10.1097/CEJ.0000000000000244</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    No association between global DNA methylation in peripherial blood and lung cancer risk in nonsmoking women: results from multicenter study in Eastern and Central Europe

  • Original language description

    Alterations in global DNA methylation have been suggested to play an important role in cancer development. We evaluated the association of global DNA methylation in peripheral blood with the risk of lung cancer in nonsmoking women from six countries in Central and Eastern Europe. This multicenter case-control study included primary, incident lung cancer cases diagnosed from 1998 to 2001 and controls frequency-matched for geographic area, sex, and age. Global methylation was assessed in peripheral blood DNA from 83 nonsmoking female cases and 181 nonsmoking female controls using the luminometric methylation assay (LUMA). Unconditional logistic regression models were used to estimate associations between DNA methylation in the blood and the risk of lung cancer. LUMA methylation level was not associated with the risk of lung cancer in nonsmoking women. Associations were not significantly different according to different strata of age, BMI, alcohol drinking, or second-hand tobacco smoke exposure status. In our study of nonsmoking women, the LUMA methylation level in peripheral blood was not associated with the risk of lung cancer. Our findings do not support an association of global blood DNA methylation with the risk of lung cancer in nonsmoking women.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30302 - Epidemiology

Result continuities

  • Project

  • Continuities

    N - Vyzkumna aktivita podporovana z neverejnych zdroju

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    European Journal of Cancer Prevention

  • ISSN

    0959-8278

  • e-ISSN

  • Volume of the periodical

    27

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    5

  • Pages from-to

    1-5

  • UT code for WoS article

    000417289000001

  • EID of the result in the Scopus database

    2-s2.0-84962352788