Left hippocampus sparing whole brain radiotherapy (WBRT): A planning study
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F17%3A00077802" target="_blank" >RIV/00209805:_____/17:00077802 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00098710 RIV/00159816:_____/17:00067615
Result on the web
<a href="http://biomed.papers.upol.cz/artkey/bio-201704-0010_left_hippocampus_sparing_whole_brain_radiotherapy_wbrt_a_planning_study.php" target="_blank" >http://biomed.papers.upol.cz/artkey/bio-201704-0010_left_hippocampus_sparing_whole_brain_radiotherapy_wbrt_a_planning_study.php</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5507/bp.2017.031" target="_blank" >10.5507/bp.2017.031</a>
Alternative languages
Result language
angličtina
Original language name
Left hippocampus sparing whole brain radiotherapy (WBRT): A planning study
Original language description
Aims. Unilateral sparing of the dominant (left) hippocampus during whole brain radiotherapy (WBRT) could mitigate cognitive decline, especially verbal memory, similar to the widely investigated bilateral hippocampus avoidance (HAWBRT). The aim of this planning study is dosimetrical comparison of HA-WBRT with only left hippocampus sparing (LHA-WBRT) plans. Methods. HA-WBRT plans for 10 patients were prepared in accordance with RTOG 0933 trial and served as baseline for comparisons with several LHA-WBRT plans prepared with an effort: 1) to maintain the same left hippocampus dosimetry ("BEST PTV") and 2) to maintain same dosimetry in planning target volume as in HA-WBRT ("BEST LH"). Results. All HA-WBRT plans met RTOG 0933 protocol criteria with a mean Conformity index 1.09 and mean Homogeneity index (HI) 0.21. Mean right and left hippocampal D100% was 7.8 Gy and 8.5 Gy and mean Dmax 14.0 Gy and 13.8 Gy, respectively. "BEST PTV" plans reduced HI by 31.2% (P=0.005) which is mirrored by lower PTV_D2% (-0.8 Gy, P=0.005) and higher PTV_D98% (+1.3 Gy, P=0.005) as well as decreased optic pathway's Dmax by 1 Gy. In "BEST LH", mean D100% and Dmax for the left hippocampus were significantly reduced by 11.2% (P=0.005) and 10.9% (P=0.005) respectively. Conclusions. LHA-WBRT could improve target coverage and/or further decrease in dose to spared hippocampus. Future clinical trials must confirm whether statistically significant reduction in left hippocampal dose is also clinically significant.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomedical papers
ISSN
1213-8118
e-ISSN
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Volume of the periodical
161
Issue of the periodical within the volume
4
Country of publishing house
CZ - CZECH REPUBLIC
Number of pages
6
Pages from-to
397-402
UT code for WoS article
000418005200010
EID of the result in the Scopus database
2-s2.0-85038371482