Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F17%3A00077834" target="_blank" >RIV/00209805:_____/17:00077834 - isvavai.cz</a>

Result on the web

<a href="http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=28223430" target="_blank" >http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=28223430</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1158/1055-9965.EPI-16-0762-T" target="_blank" >10.1158/1055-9965.EPI-16-0762-T</a>

Result language

angličtina

Original language name

Young Adult and Usual Adult Body Mass Index and Multiple Myeloma Risk: A Pooled Analysis in the International Multiple Myeloma Consortium (IMMC)

Original language description

Background: Multiple myeloma risk increases with higher adult body mass index (BMI). Emerging evidence also supports an association of young adult BMI with multiple myeloma. We undertook a pooled analysis of eight case-control studies to further evaluate anthropometric multiple myeloma risk factors, including young adult BMI. Methods: We conducted multivariable logistic regression analysis of usual adult anthropometric measures of 2,318 multiple myeloma cases and 9,609 controls, and of young adult BMI (age 25 or 30 years) for 1,164 cases and 3,629 controls. Results: In the pooled sample, multiple myeloma risk was positively associated with usual adult BMI; risk increased 9% per 5-kg/m2 increase in BMI [OR, 1.09; 95% confidence interval (CI), 1.04-1.14; P 1/4 0.007]. We observed significant heterogeneity by study design (P 1/4 0.04), noting the BMI-multiple myeloma association only for population-based studies (Ptrend1/4 0.0003). Young adult BMI was also positively associated with multiple myeloma (per 5-kg/m2; OR, 1.2; 95%CI, 1.1-1.3; P1/4 0.0002). Furthermore, we observed strong evidence of interaction between younger and usual adult BMI (Pinteraction &lt;0.0001); we noted statistically significant associations with multiple myeloma for persons overweight (25-&lt;30 kg/m2) or obese (30þ kg/m2) in both younger and usual adulthood (vs. individuals consistently &lt;25 kg/m2), but not for those overweight or obese at only one time period. Conclusions: BMI-associated increases in multiple myeloma risk were highest for individuals who were overweight or obese throughout adulthood. Impact: These findings provide the strongest evidence to date that earlier and later adult BMI may increase multiple myeloma risk and suggest that healthy BMI maintenance throughout life may confer an added benefit of multiple myeloma prevention.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/ED2.1.00%2F03.0101" target="_blank" >ED2.1.00/03.0101: Regional Centre for Applied Molecular Oncology (RECAMO)</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancer epidemiology, biomarkers &amp; prevention

ISSN

1055-9965

e-ISSN

—

Volume of the periodical

26

Issue of the periodical within the volume

6

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

876-885

UT code for WoS article

000402765600009

EID of the result in the Scopus database

2-s2.0-85020232130