Titanocenes as anticancer agents: recent insights

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F17%3A00077873" target="_blank" >RIV/00209805:_____/17:00077873 - isvavai.cz</a>

Result on the web

<a href="http://www.eurekaselect.com/148762/article" target="_blank" >http://www.eurekaselect.com/148762/article</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.2174/1573406412666161228113650" target="_blank" >10.2174/1573406412666161228113650</a>

Result language

angličtina

Original language name

Titanocenes as anticancer agents: recent insights

Original language description

Enormous success of antitumor agent cisplatin initiated interest in other organometallic complexes. A subclass of organometallic compounds termed metallocenes, characterized by a transition metal central atom (M) bound to cyclopentadienide (Cp-/[C5H5]-) ligands with the basic formula Cp2M, has gained increasing interest as promising anticancer agents. This review is aimed at a progress in the development of organometallic titanium-based compounds focusing primarily on the evaluation of their cytotoxic activity and mechanism of action in relation to potential utilization as anticancer drugs. Metallocenes bearing titanium as central atom were sorted according to their structure and modifications and their anticancer activity is further discussed. Titanocenes represent family of promising compounds exerting cytostatic activity. We suggest that their application not only as separate agents, but also in combination with newly developed carriers, e.g. nanomaterials, may lead to improvement of their delivery into tumor cells and following utilization in cancer treatment.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

<a href="/en/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year

2017

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Medicinal chemistry

ISSN

1573-4064

e-ISSN

—

Volume of the periodical

13

Issue of the periodical within the volume

4

Country of publishing house

AE - UNITED ARAB EMIRATES

Number of pages

11

Pages from-to

334-344

UT code for WoS article

000402479000003

EID of the result in the Scopus database

2-s2.0-85020793064