Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F17%3A00077913" target="_blank" >RIV/00209805:_____/17:00077913 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/17:00124647
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715504/pdf/lupus-2016-000187.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715504/pdf/lupus-2016-000187.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1136/lupus-2016-000187" target="_blank" >10.1136/lupus-2016-000187</a>

Result language
angličtina
Original language name
Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma
Original language description
Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genome-wide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. These data suggest several plausible genetic links between DLBCL and SLE.
Czech name
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Czech description
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Type
J<sub>SC</sub> - Article in a specialist periodical, which is included in the SCOPUS database
CEP classification
—
OECD FORD branch
30204 - Oncology

Project
<a href="/en/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2017
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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