STAT3, stem cells, cancer stem cells and p63
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00077980" target="_blank" >RIV/00209805:_____/18:00077980 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863838/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863838/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s11658-018-0078-0" target="_blank" >10.1186/s11658-018-0078-0</a>
Alternative languages
Result language
angličtina
Original language name
STAT3, stem cells, cancer stem cells and p63
Original language description
Signal Transducer and Activator of Transcription 3 (STAT3) is a transcription factor with many important functions in the biology of normal and transformed cells. Its regulation is highly complex as it is involved in signaling pathways in many different cell types and under a wide variety of conditions. Besides other functions, STAT3 is an important regulator of normal stem cells and cancer stem cells. p63 which is a member of the p53 protein family is also involved in these functions and is both physically and functionally connected with STAT3. This review summarizes STAT3 function and regulation, its role in stem cell and cancer stem cell properties and highlights recent reports about its relationship to p63.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cellular & molecular biology letters
ISSN
1425-8153
e-ISSN
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Volume of the periodical
23
Issue of the periodical within the volume
22.3.2018
Country of publishing house
GB - UNITED KINGDOM
Number of pages
20
Pages from-to
12
UT code for WoS article
000428298800001
EID of the result in the Scopus database
2-s2.0-85044297781