The role of p63 in cancer, stem cells and cancer stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F11%3A%230000147" target="_blank" >RIV/00209805:_____/11:#0000147 - isvavai.cz</a>
Result on the web
<a href="http://www.springerlink.com/content/9801w775x3587419/?MUD=MP" target="_blank" >http://www.springerlink.com/content/9801w775x3587419/?MUD=MP</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2478/s11658-011-0009-9" target="_blank" >10.2478/s11658-011-0009-9</a>
Alternative languages
Result language
angličtina
Original language name
The role of p63 in cancer, stem cells and cancer stem cells
Original language description
The transcription factor p63 has important functions in tumorigenesis, epidermal differentiation and stem cell self-renewal. The TP63 gene encodes multiple protein isoforms that have different or even antagonistic roles in these processes. The balance ofp63 isoforms, together with the presence or absence of the other p53 family members, p73 and p53, has a striking biological impact. There is increasing evidence that interactions between p53-family members, whether cooperative or antagonistic, are involved in various cell processes. This review summarizes the current understanding of the role of p63 in tumorigenesis, metastasis, cell migration and senescence. In particular, recent data indicate important roles in adult stem cell and cancer stem cell regulation and in the response of cancer cells to therapy.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Cellular and molecular biology letters
ISSN
1425-8153
e-ISSN
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Volume of the periodical
16
Issue of the periodical within the volume
2
Country of publishing house
PL - POLAND
Number of pages
32
Pages from-to
296-327
UT code for WoS article
000288798300008
EID of the result in the Scopus database
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