Searching For New Targets And Treatments In The Battle Against Squamous Cell Carcinoma Of The Head And Neck, With Specific Focus On Tumours Of The Tongue
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078002" target="_blank" >RIV/00209805:_____/18:00078002 - isvavai.cz</a>
Result on the web
<a href="http://www.eurekaselect.com/159089/article" target="_blank" >http://www.eurekaselect.com/159089/article</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.2174/1568026618666180116121624" target="_blank" >10.2174/1568026618666180116121624</a>
Alternative languages
Result language
angličtina
Original language name
Searching For New Targets And Treatments In The Battle Against Squamous Cell Carcinoma Of The Head And Neck, With Specific Focus On Tumours Of The Tongue
Original language description
Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning the site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide, an increasing number of people LESS-THAN OR EQUAL TO 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis, up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review, field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from the analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
<a href="/en/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Current topics in medicinal chemistry
ISSN
1568-0266
e-ISSN
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Volume of the periodical
18
Issue of the periodical within the volume
3
Country of publishing house
NL - THE KINGDOM OF THE NETHERLANDS
Number of pages
5
Pages from-to
214-218
UT code for WoS article
000432250800006
EID of the result in the Scopus database
2-s2.0-85047745626