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Searching For New Targets And Treatments In The Battle Against Squamous Cell Carcinoma Of The Head And Neck, With Specific Focus On Tumours Of The Tongue

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078002" target="_blank" >RIV/00209805:_____/18:00078002 - isvavai.cz</a>

  • Result on the web

    <a href="http://www.eurekaselect.com/159089/article" target="_blank" >http://www.eurekaselect.com/159089/article</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.2174/1568026618666180116121624" target="_blank" >10.2174/1568026618666180116121624</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Searching For New Targets And Treatments In The Battle Against Squamous Cell Carcinoma Of The Head And Neck, With Specific Focus On Tumours Of The Tongue

  • Original language description

    Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning the site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide, an increasing number of people LESS-THAN OR EQUAL TO 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis, up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review, field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from the analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

    <a href="/en/project/LO1413" target="_blank" >LO1413: RECAMO2020</a><br>

  • Continuities

    P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Current topics in medicinal chemistry

  • ISSN

    1568-0266

  • e-ISSN

  • Volume of the periodical

    18

  • Issue of the periodical within the volume

    3

  • Country of publishing house

    NL - THE KINGDOM OF THE NETHERLANDS

  • Number of pages

    5

  • Pages from-to

    214-218

  • UT code for WoS article

    000432250800006

  • EID of the result in the Scopus database

    2-s2.0-85047745626