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Levels of MUC1 in tumours and serum of patients with different sub-types of squamous cell carcinoma of the head and neck

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078421" target="_blank" >RIV/00209805:_____/20:00078421 - isvavai.cz</a>

  • Result on the web

    <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377060/pdf/ol-20-02-1709.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377060/pdf/ol-20-02-1709.pdf</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.3892/ol.2020.11746" target="_blank" >10.3892/ol.2020.11746</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Levels of MUC1 in tumours and serum of patients with different sub-types of squamous cell carcinoma of the head and neck

  • Original language description

    Mucin 1 (MUC1) is a membrane-bound and secreted glycoprotein that has a protective role in surface epithelia. We recently demonstrated that MUC1 mRNA expression was upregulated in tumour-free tongue tissues adjacent to squamous cell carcinoma of the oral tongue (SCCOT) compared with that in the tumour tissues. The present study investigated MUC1 protein in SCCOT tissue and serum from patients with squamous cell carcinoma of the head and neck (SCCHN) at different sub-sites. The results from immunohistochemistry demonstrated that all SCCOT tissues expressed MUC1; however, the protein levels were not correlated with MUC1 mRNA levels in the same tumours. Furthermore, serum MUC1 level was lower in patients with SCCOT, tonsil SCC and gingival SCC compared with that in healthy subjects; however, the difference was only significant for patients with SCCOT (P=0.0421). No correlation was seen between MUC1 level in tumour tissues and MUCI level in serum from the same patients. The absence of correlation between MUC1 protein and mRNA levels in SCCOT tissues emphasized the importance of validating genomic data in clinical samples. Although significant MUC1 downregulation was observed in the serum of patients with SCCOT, there was a large variation within the groups, suggesting that MUC1 may not be used as a biomarker for these types of tumors.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    10608 - Biochemistry and molecular biology

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2020

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Oncology letters

  • ISSN

    1792-1074

  • e-ISSN

  • Volume of the periodical

    20

  • Issue of the periodical within the volume

    2

  • Country of publishing house

    GR - GREECE

  • Number of pages

    10

  • Pages from-to

    1709-1718

  • UT code for WoS article

    000563832100076

  • EID of the result in the Scopus database

    2-s2.0-85087204210