Levels of MUC1 in tumours and serum of patients with different sub-types of squamous cell carcinoma of the head and neck
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078421" target="_blank" >RIV/00209805:_____/20:00078421 - isvavai.cz</a>
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377060/pdf/ol-20-02-1709.pdf" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7377060/pdf/ol-20-02-1709.pdf</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.3892/ol.2020.11746" target="_blank" >10.3892/ol.2020.11746</a>
Alternative languages
Result language
angličtina
Original language name
Levels of MUC1 in tumours and serum of patients with different sub-types of squamous cell carcinoma of the head and neck
Original language description
Mucin 1 (MUC1) is a membrane-bound and secreted glycoprotein that has a protective role in surface epithelia. We recently demonstrated that MUC1 mRNA expression was upregulated in tumour-free tongue tissues adjacent to squamous cell carcinoma of the oral tongue (SCCOT) compared with that in the tumour tissues. The present study investigated MUC1 protein in SCCOT tissue and serum from patients with squamous cell carcinoma of the head and neck (SCCHN) at different sub-sites. The results from immunohistochemistry demonstrated that all SCCOT tissues expressed MUC1; however, the protein levels were not correlated with MUC1 mRNA levels in the same tumours. Furthermore, serum MUC1 level was lower in patients with SCCOT, tonsil SCC and gingival SCC compared with that in healthy subjects; however, the difference was only significant for patients with SCCOT (P=0.0421). No correlation was seen between MUC1 level in tumour tissues and MUCI level in serum from the same patients. The absence of correlation between MUC1 protein and mRNA levels in SCCOT tissues emphasized the importance of validating genomic data in clinical samples. Although significant MUC1 downregulation was observed in the serum of patients with SCCOT, there was a large variation within the groups, suggesting that MUC1 may not be used as a biomarker for these types of tumors.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
10608 - Biochemistry and molecular biology
Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oncology letters
ISSN
1792-1074
e-ISSN
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Volume of the periodical
20
Issue of the periodical within the volume
2
Country of publishing house
GR - GREECE
Number of pages
10
Pages from-to
1709-1718
UT code for WoS article
000563832100076
EID of the result in the Scopus database
2-s2.0-85087204210