Expression of CD44, EGFR, p16, and their mutual combinationsin patients with head and neck cancer: Impact on outcomes ofintensit y-modulated radiation therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078100" target="_blank" >RIV/00209805:_____/18:00078100 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/19:00108450 RIV/00159816:_____/19:00071245 RIV/00209805:_____/19:00078100 RIV/00209805:_____/19:00078581
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25533" target="_blank" >https://onlinelibrary.wiley.com/doi/abs/10.1002/hed.25533</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/hed.25533" target="_blank" >10.1002/hed.25533</a>

Result language
angličtina
Original language name
Expression of CD44, EGFR, p16, and their mutual combinationsin patients with head and neck cancer: Impact on outcomes ofintensit y-modulated radiation therapy
Original language description
Background: Progress in radiation treatment of head and neck squamous cell car-cinoma (HNSCC) deserves the studies focused on molecular predictors that wouldhelp to enhance individually tailored treatment.Methods: p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.Results: In the entire group and the p16 negative cohort, better 3-year overall sur-vival and locoregional control correlated with p16 positivity, CD44, and EGFRnegativity were observed. Combined analysis revealed the worst results in theCD44+/p16- , EGFR+/p16- , and EGFR+ /CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Kar-nofsky index, p16, and CD44 as prognostic factors of overall survival and clinicalstage, and p16 as a progn ostic factor for locoregional control. Clinical stage andKarnofsky index affected overall survival and tumor stage. EGFR affected locore-gional control in the p16 negative subgroup.Conclusion: Our study confirmed the negative effect of CD44 and EGF R and thepositive effect of p16 on radiotherapy results.
Czech name
—
Czech description
—

Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
—
OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Similar results(10)