Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078581" target="_blank" >RIV/00209805:_____/19:00078581 - isvavai.cz</a>
Alternative codes found
RIV/00209805:_____/18:00078100 RIV/00216224:14110/19:00108450 RIV/00159816:_____/19:00071245 RIV/00209805:_____/19:00078100
Result on the web
<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.25533" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/hed.25533</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1002/hed.25533" target="_blank" >10.1002/hed.25533</a>

Result language
angličtina
Original language name
Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy
Original language description
Background: Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment. Methods: p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients. Results: In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Combined analysis revealed the worst results in the CD44+/p16-, EGFR+/p16-, and EGFR+/CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Karnofsky index, p16, and CD44 as prognostic factors of overall survival and clinical stage, and p16 as a prognostic factor for locoregional control. Clinical stage and Karnofsky index affected overall survival and tumor stage. EGFR affected locoregional control in the p16 negative subgroup. Conclusion: Our study confirmed the negative effect of CD44 and EGFR and the positive effect of p16 on radiotherapy results.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Publication year
2019
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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