Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078101" target="_blank" >RIV/00209805:_____/18:00078101 - isvavai.cz</a>
Alternative codes found
RIV/68081707:_____/18:00492427 RIV/00159816:_____/18:00068657 RIV/00216224:14310/18:00106565
Result on the web
<a href="https://www.nature.com/articles/bjc2017497" target="_blank" >https://www.nature.com/articles/bjc2017497</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1038/bjc.2017.497" target="_blank" >10.1038/bjc.2017.497</a>
Alternative languages
Result language
angličtina
Original language name
Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer
Original language description
The intratumoural heterogeneity, often driven by epithelial-to-mesenchymal transition (EMT), significantly contributes to chemoresistance and disease progression in adenocarcinomas. Methods: We introduced a high-throughput screening platform to identify surface antigens that associate with epithelial- mesenchymal plasticity in well-defined pairs of epithelial cell lines and their mesenchymal counterparts. Using multicolour flow cytometry, we then analysed the expression of 10 most robustly changed antigens and identified a 10-molecule surface signature, in pan-cytokeratin-positive/EpCAM-positive and -negative fractions of dissociated breast tumours. Results: We found that surface CD9, CD29, CD49c, and integrin b5 are lost in breast cancer cells that underwent EMT in vivo. The tetraspanin family member CD9 was concordantly downregulated both in vitro and in vivo and associated with epithelial phenotype and favourable prognosis. Conclusions: We propose that overall landscape of 10-molecule surface signature expression reflects the epithelial-mesenchymal plasticity in breast cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
—
Continuities
—
Others
Publication year
2018
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
British Journal of Cancer
ISSN
0007-0920
e-ISSN
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Volume of the periodical
118
Issue of the periodical within the volume
6
Country of publishing house
GB - UNITED KINGDOM
Number of pages
7
Pages from-to
813-819
UT code for WoS article
000427945800020
EID of the result in the Scopus database
2-s2.0-85044196932