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Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F18%3A00078101" target="_blank" >RIV/00209805:_____/18:00078101 - isvavai.cz</a>

  • Alternative codes found

    RIV/68081707:_____/18:00492427 RIV/00159816:_____/18:00068657 RIV/00216224:14310/18:00106565

  • Result on the web

    <a href="https://www.nature.com/articles/bjc2017497" target="_blank" >https://www.nature.com/articles/bjc2017497</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1038/bjc.2017.497" target="_blank" >10.1038/bjc.2017.497</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Plasticity and intratumoural heterogeneity of cell surface antigen expression in breast cancer

  • Original language description

    The intratumoural heterogeneity, often driven by epithelial-to-mesenchymal transition (EMT), significantly contributes to chemoresistance and disease progression in adenocarcinomas. Methods: We introduced a high-throughput screening platform to identify surface antigens that associate with epithelial- mesenchymal plasticity in well-defined pairs of epithelial cell lines and their mesenchymal counterparts. Using multicolour flow cytometry, we then analysed the expression of 10 most robustly changed antigens and identified a 10-molecule surface signature, in pan-cytokeratin-positive/EpCAM-positive and -negative fractions of dissociated breast tumours. Results: We found that surface CD9, CD29, CD49c, and integrin b5 are lost in breast cancer cells that underwent EMT in vivo. The tetraspanin family member CD9 was concordantly downregulated both in vitro and in vivo and associated with epithelial phenotype and favourable prognosis. Conclusions: We propose that overall landscape of 10-molecule surface signature expression reflects the epithelial-mesenchymal plasticity in breast cancer.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30204 - Oncology

Result continuities

  • Project

  • Continuities

Others

  • Publication year

    2018

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    British Journal of Cancer

  • ISSN

    0007-0920

  • e-ISSN

  • Volume of the periodical

    118

  • Issue of the periodical within the volume

    6

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    7

  • Pages from-to

    813-819

  • UT code for WoS article

    000427945800020

  • EID of the result in the Scopus database

    2-s2.0-85044196932