MicroRNA Biogenesis Pathway Genes Are Deregulated in Colorectal Cancer

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F19%3A00078282" target="_blank" >RIV/00209805:_____/19:00078282 - isvavai.cz</a>

Alternative codes found

RIV/65269705:_____/19:00071214 RIV/00216224:14740/19:00108569

Result on the web

<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770105/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770105/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ijms20184460" target="_blank" >10.3390/ijms20184460</a>

Result language

angličtina

Original language name

MicroRNA Biogenesis Pathway Genes Are Deregulated in Colorectal Cancer

Original language description

MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally regulate gene expression. Each step of their production and maturation has to be strictly regulated, as any disruption of control mechanisms may lead to cancer. Thus, we have measured the expression of 19 genes involved in miRNAs biogenesis pathway in tumor tissues of 239 colorectal cancer (CRC) patients, 17 CRC patients with liver metastases and 239 adjacent tissues using real-time PCR. Subsequently, the expression of analyzed genes was correlated with the clinical-pathological features as well as with the survival of patients. In total, significant over-expression of all analyzed genes was observed in tumor tissues as well as in liver metastases except for LIN28A/B. Furthermore, it was shown that the deregulated levels of some of the analyzed genes significantly correlate with tumor stage, grade, location, size and lymph node positivity. Finally, high levels of DROSHA and TARBP2 were associated with shorter disease-free survival, while the over-expression of XPO5, TNRC6A and DDX17 was detected in tissues of patients with shorter overall survival and poor prognosis. Our data indicate that changed levels of miRNA biogenesis genes may contribute to origin as well as progression of CRC; thus, these molecules could serve as potential therapeutic targets.

Czech name

—

Czech description

—

Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

—

OECD FORD branch

30204 - Oncology

Project

Result was created during the realization of more than one project. More information in the Projects tab.

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2019

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

International journal of molecular sciences

ISSN

1422-0067

e-ISSN

—

Volume of the periodical

20

Issue of the periodical within the volume

18

Country of publishing house

CH - SWITZERLAND

Number of pages

13

Pages from-to

"E4460"

UT code for WoS article

000489100500139

EID of the result in the Scopus database

2-s2.0-85072145176