PD-L1 in Squamous Cell Carcinoma of the Oral Tongue Shows Gender-Specific Association With Prognosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078402" target="_blank" >RIV/00209805:_____/20:00078402 - isvavai.cz</a>
Result on the web
<a href="https://pubmed.ncbi.nlm.nih.gov/32406589/?from_term=coates+pj&from_sort=date&from_pos=1" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/32406589/?from_term=coates+pj&from_sort=date&from_pos=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/odi.13414" target="_blank" >10.1111/odi.13414</a>
Alternative languages
Result language
angličtina
Original language name
PD-L1 in Squamous Cell Carcinoma of the Oral Tongue Shows Gender-Specific Association With Prognosis
Original language description
Objective: To use alternative quantitation approaches to clarify the clinical implication of programmed cell death ligand 1 (PD-L1) in squamous cell carcinoma of the oral tongue (SCCOT). Materials and methods: Ventana SP263 immunohistochemistry assay and a multiplicative QuickScore method were applied to quantify PD-L1 in tumor and surrounding immune cells from 101 patients with SCCOT. Tumor-infiltrating immune cells were estimated from bulk tissue transcriptional profiles of 25 patients. Circulating PD-L1 levels were measured in serum from 30 patients using an electrochemiluminescence assay platform. Results: We found higher tumor cell PD-L1 levels in females than males (P = 0.019). For patients with low PD-L1 in tumor cells, better survival was seen in males than females (overall survival P = 0.021, disease-free survival P = 0.020). Tumor-infiltrating natural killer T cells, immature dendritic cells and M1 macrophages were positively associated with tumor cell PD-L1 (P < 0.05). Conclusions: Our data confirmed the significance of gender on tumor cell PD-L1 expression and demonstrated combined effects of gender and PD-L1 levels on clinical outcome in patients with SCCOT. The data also indicated the involvement of specific immune cell types in PD-L1 regulated immune evasion.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Others
Publication year
2020
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Oral Diseases
ISSN
1354-523X
e-ISSN
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Volume of the periodical
26
Issue of the periodical within the volume
7
Country of publishing house
DK - DENMARK
Number of pages
10
Pages from-to
"1414–1423"
UT code for WoS article
000545475200001
EID of the result in the Scopus database
2-s2.0-85087561132