lncRNA and Mechanisms of Drug Resistance in Cancers of the Genitourinary System

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F20%3A00078445" target="_blank" >RIV/00209805:_____/20:00078445 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14740/20:00118389

Result on the web

<a href="https://pubmed.ncbi.nlm.nih.gov/32756406/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/32756406/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/cancers12082148" target="_blank" >10.3390/cancers12082148</a>

Result language

angličtina

Original language name

lncRNA and Mechanisms of Drug Resistance in Cancers of the Genitourinary System

Original language description

Available systemic treatment options for cancers of the genitourinary system have experienced great progress in the last decade. However, a large proportion of patients eventually develop resistance to treatment, resulting in disease progression and shorter overall survival. Biomarkers indicating the increasing resistance to cancer therapies are yet to enter clinical routine. Long non-coding RNAs (lncRNA) are non-protein coding RNA transcripts longer than 200 nucleotides that exert multiple types of regulatory functions of all known cellular processes. Increasing evidence supports the role of lncRNAs in cancer development and progression. Additionally, their involvement in the development of drug resistance across various cancer entities, including genitourinary malignancies, are starting to be discovered. Consequently, lncRNAs have been suggested as factors in novel therapeutic strategies to overcome drug resistance in cancer. In this review, the existing evidences on lncRNAs and their involvement in mechanisms of drug resistance in cancers of the genitourinary system, including renal cell carcinoma, bladder cancer, prostate cancer, and testicular cancer, will be highlighted and discussed to facilitate and encourage further research in this field. We summarize a significant number of lncRNAs with proposed pathways in drug resistance and available reported studies.

Czech name

—

Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2020

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Cancers

ISSN

2072-6694

e-ISSN

—

Volume of the periodical

12

Issue of the periodical within the volume

8

Country of publishing house

CH - SWITZERLAND

Number of pages

28

Pages from-to

2148

UT code for WoS article

000578922800001

EID of the result in the Scopus database

2-s2.0-85090324562