Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079645" target="_blank" >RIV/00209805:_____/24:00079645 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00136172 RIV/00216208:11110/24:10475832 RIV/65269705:_____/24:00079460
Result on the web
<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836005/" target="_blank" >https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10836005/</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1186/s40364-024-00563-3" target="_blank" >10.1186/s40364-024-00563-3</a>
Alternative languages
Result language
angličtina
Original language name
Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells
Original language description
Small noncoding RNAs play an important role in various disease states, including cancer. PIWI proteins, a subfamily of Argonaute proteins, and PIWI-interacting RNAs (piRNAs) were originally described as germline-specific molecules that inhibit the deleterious activity of transposable elements. However, several studies have suggested a role for the piRNA-PIWI axis in somatic cells, including somatic stem cells. Dysregulated expression of piRNAs and PIWI proteins in human tumors implies that, analogously to their roles in undifferentiated cells under physiological conditions, these molecules may be important for cancer stem cells and thus contribute to cancer progression. We provide an overview of piRNA biogenesis and critically review the evidence for the role of piRNA-PIWI axis in cancer stem cells. In addition, we examine the potential of piRNAs and PIWI proteins to become biomarkers in cancer.
Czech name
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Czech description
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Classification
Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology
Result continuities
Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Biomarker Research
ISSN
2050-7771
e-ISSN
2050-7771
Volume of the periodical
12
Issue of the periodical within the volume
1
Country of publishing house
GB - UNITED KINGDOM
Number of pages
24
Pages from-to
15
UT code for WoS article
001155019100001
EID of the result in the Scopus database
2-s2.0-85183690921