Dataset of DNA methylation profiles of 189 pediatric central nervous system, soft tissue, and bone tumors

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F24%3A00079822" target="_blank" >RIV/00209805:_____/24:00079822 - isvavai.cz</a>
Alternative codes found
RIV/00216224:14110/24:00136799 RIV/65269705:_____/24:00080213
Result on the web
<a href="https://www.sciencedirect.com/science/article/pii/S2352340924005572" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2352340924005572</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.dib.2024.110590" target="_blank" >10.1016/j.dib.2024.110590</a>

Result language
angličtina
Original language name
Dataset of DNA methylation profiles of 189 pediatric central nervous system, soft tissue, and bone tumors
Original language description
Alterations in DNA methylation profiles belong to important mechanisms in cancer development, and their assessment can be utilized for rapid and precise diagnostics. Therefore, establishing datasets of methylation profiles can improve and deepen our understanding of the role of epigenetic changes in cancer development as well as improve our diagnostic capabilities. In this dataset, we generated NGS data for 189 samples of pediatric CNS, soft tissue, and bone tumors. The sequencing libraries were prepared using methyl capture bisulfite sequencing, an effective compromise between whole-genome bisulfite sequencing and array-based methods with a more limited scope of target regions. The larger part of the cohort was processed with the Agilent SureSelectXT Human Methyl-Seq kit (149 samples) and the rest with the Illumina TruSeq Methyl Capture EPIC Library Prep Kit (40 samples). The data presented in this article may help other researchers further elucidate the importance of methylation in diagnosing pediatric CNS tumors, soft tissue, and bone tumors.
Czech name
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Czech description
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Type
J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database
CEP classification
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OECD FORD branch
30204 - Oncology

Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2024
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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