Sex differences in the incidence trends of early-onset gastrointestinal cancer - the European/Mediterranean perspective

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00209805%3A_____%2F25%3A00080512" target="_blank" >RIV/00209805:_____/25:00080512 - isvavai.cz</a>

Alternative codes found

RIV/00216224:14110/25:00143803

Result on the web

<a href="https://www.sciencedirect.com/science/article/pii/S2949819825001074" target="_blank" >https://www.sciencedirect.com/science/article/pii/S2949819825001074</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.esmogo.2025.100238" target="_blank" >10.1016/j.esmogo.2025.100238</a>

Result language

angličtina

Original language name

Sex differences in the incidence trends of early-onset gastrointestinal cancer - the European/Mediterranean perspective

Original language description

BackgroundWhile the rising incidence of early-onset colorectal cancer has been documented worldwide, there is a paucity of data on the epidemiological changes in other gastrointestinal (GI) cancers in the young population in Europe. We sought to characterize incidence patterns of GI cancers in young patients in different European/Mediterranean countries.Patients and methodsNational cancer registries in several European countries were contacted to obtain the absolute number of GI cancer cases per age group (15-49 years) at 5-year intervals and the absolute population size for each of these age groups annually from 2008 to 2018. Data were analyzed to calculate year-to-year incidence rate change and average annual percentage change.ResultsSeven countries were included in the analysis: the Czech Republic, Germany, Israel, the Netherlands, Norway, Slovenia, and Spain. Different trends were observed for different GI cancers. For colorectal cancer, all countries except Germany showed increasing incidence rates in a similar pattern for males and females. An increasing trend in pancreatic cancer was documented in the Czech Republic, more in males, and in Slovenia and Israel significantly more in females. There was a slight increase in Spain and Germany, with no difference by sex. The incidence of early-onset gastric and esophageal cancer was very low and non-rising.ConclusionsEarly-onset cancers along the GI tract show different patterns in different European countries. For some types of GI tumors the incidence was fairly stable between 2008 and 2018 while some were increasing, in particular colorectal cancer in both sexes, and pancreatic cancer in females.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

30204 - Oncology

Project

—

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2025

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

ESMO Gastrointestinal Oncology

ISSN

2949-8198

e-ISSN

—

Volume of the periodical

10

Issue of the periodical within the volume

December 2025

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

8

Pages from-to

100238

UT code for WoS article

001633891600003

EID of the result in the Scopus database

2-s2.0-105015784373