Use of the Leksell gamma knife in the treatment of prolactinoma patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F09%3A3746" target="_blank" >RIV/00216208:11110/09:3746 - isvavai.cz</a>

Alternative codes found

RIV/67985807:_____/09:00337772 RIV/00064165:_____/09:3746

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Use of the Leksell gamma knife in the treatment of prolactinoma patients

Original language description

We describe our 12-year experience in treating prolactinomas with the Leksell gamma knife (LGK). We followed 35 prolactinoma patients (25.7% microprolactinomas, 74.3% macroprolactinomas) treated with LGK irradiation. The mean follow-up period was 75.5 months. Prior to LGK irradiation, patients were treated with DA and 10 of them (28.6%) underwent neurosurgery. Indications for LGK irradiation were: DA intolerance (31.4%), DA resistance (45.7%) and efforts to reduce the DA dose or shorten the period of administration (22.9%). Pituitary function was monitored regularly at 6-month intervals. The central radiation dose range was 40-80 Gy (median 70 Gy), and the minimal peripheral dose was 20-49 Gy (median 34 Gy). Normoprolactinaemia was achieved in 37.1% ofthe patients who discontinued DA and in 42.9% of patients who continued DA treatment after LGK irradiation. No relapse was seen in any patient. The size of adenoma decreased even in those patients in whom it was not changed by previous D

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical endocrinology

ISSN

0300-0664

e-ISSN

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Volume of the periodical

70

Issue of the periodical within the volume

5

Country of publishing house

GB - UNITED KINGDOM

Number of pages

10

Pages from-to

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UT code for WoS article

000264563800012

EID of the result in the Scopus database

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