The apo(a) gene (TTTTA)(n) promoter polymorphism and its association with variability in exons of the kringle IV types 8 to 10

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F09%3A4884" target="_blank" >RIV/00216208:11110/09:4884 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/09:4884

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

The apo(a) gene (TTTTA)(n) promoter polymorphism and its association with variability in exons of the kringle IV types 8 to 10

Original language description

The (TTTTA)(n) repetition from the promoter of the apo(a) gene is supposed to be a relevant candidate for the additional regulation of lipoprotein (a) levels. We scanned the kringle IV types 8-10 of the apo(a) gene for candidate variants that could be atleast partly responsible for the (TTTTA)(n) repetition effect. The selected sample group comprises of 160 unrelated individuals designed to cover a representative amount even of the rare TTTTA(n) allele carriers. The high resolution melting method was used to scan exons of selected kringles for alteration. Linkage disequilibrium and haplotype frequencies were assigned using Arlequine software. Overall eight different sequence variants were detected from which all but two were rare (c.66A-->C; c.74C-->T; c.133G-->A; c.154C-->T;+1G-->A 5'splice site; c.16G-->T; c.61G-->A; c.63C-->T). However the TTTTA(n) repetition was in allelic association with all five tested polymorphic loci (P<0.0023).

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

EB - Genetics and molecular biology

OECD FORD branch

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Project

<a href="/en/project/NR9411" target="_blank" >NR9411: Genetic determination of the hypolipidemic treatment efficacy</a><br>

Continuities

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year

2009

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinica chimica acta

ISSN

0009-8981

e-ISSN

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Volume of the periodical

405

Issue of the periodical within the volume

1-2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

4

Pages from-to

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UT code for WoS article

000267448300007

EID of the result in the Scopus database

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