The influence of apolipoprotein A5 T-1131C and apolipoprotein E common genetic variants on the levels of hemostatic markers in dyslipidemi patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150300" target="_blank" >RIV/61989592:15110/14:33150300 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/14:#0000738

Result on the web

<a href="http://dx.doi.org/10.1016/j.cca.2014.04.029" target="_blank" >http://dx.doi.org/10.1016/j.cca.2014.04.029</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.cca.2014.04.029" target="_blank" >10.1016/j.cca.2014.04.029</a>

Result language

angličtina

Original language name

The influence of apolipoprotein A5 T-1131C and apolipoprotein E common genetic variants on the levels of hemostatic markers in dyslipidemi patients

Original language description

Objectives: The aim of this study was to valuate the relationsips of the T-1131C (rs662799) polymorphism variants of apolipoprotein A5 (Apo A5) gene and variants of apolipoprotein E (Apo E) gene common polymorphism (rs429358, rs7412) to selected hemostatic markers. Study design and methods: We examined 590 asymptomatic dyslipidemic patients, subsequently divided into MetS + (n = 146) a MetS - (n = 444) groups according to the criteria for identification of the metabolic syndrome (MetS). We compared variant frequencies and differences in levels of hemostatic markers according to Apo A5, Apo E and Apo A5/Apo E common variants. Results: The 1131C Apo A5 minor variant was associated with elevated tissue plasminogen activator (tPA) in comparison to TT genotype (p{ 0,001), but not in the MetS + group. The analysis of Apo A5/Apo E common variants in all subjects revealed that the presence of -1131C minor allele has always been associated with higher levels of tP in comparison with T allele, r

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinica Chimica Acta

ISSN

0009-8981

e-ISSN

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Volume of the periodical

436

Issue of the periodical within the volume

duben

Country of publishing house

NL - THE KINGDOM OF THE NETHERLANDS

Number of pages

7

Pages from-to

11-17

UT code for WoS article

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EID of the result in the Scopus database

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