Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15110%2F14%3A33150160" target="_blank" >RIV/61989592:15110/14:33150160 - isvavai.cz</a>

Alternative codes found

RIV/00098892:_____/14:#0000721

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Genetic variants of apolipoprotein A5 T-1131C and apolipoprotein E common polymorphisms and their relationship to features of metabolic syndrome in adult dyslipidemic patients

Original language description

Objectives: The aim was to evaluate the relationships of the T-1131C (rs662799) polymorphism variants of apolipoprotein A5 (Apo A5) gene and variants of apolipopprotein E (ApoE) gene common polymorphism (rs429358,rs7412) to signs of metabolic syndrome (MetS). Design and methods: We examined 590 asymptomatic dyslipidemic patients divided into MetS + (n=146) and MetS - (n=444) groups according to criteria of NCEP ATPIII Panel. We evaluated genotype frequencies and differences in MetS feature between individual groups. Logistic regression analysis wes used for the evaluation of Apo A5/ApoE variants as possible risk factors for MetS. Conclusion: Our study refined the role of Apo A5 and Apo E genetic variants in the group of adult dyslipidemic patients. Wedemonstrate that except of TG, Apo A5 T-1131C (rs662799) and Apo E (rs429358, rs7412) polymorphisms have no remarkable effect on MetS characteristics.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FP - Other medical fields

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2014

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Clinical Biochemistry

ISSN

0009-9120

e-ISSN

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Volume of the periodical

47

Issue of the periodical within the volume

12

Country of publishing house

US - UNITED STATES

Number of pages

7

Pages from-to

1015-1021

UT code for WoS article

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EID of the result in the Scopus database

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