Regulation of Diurnal Variation of Cholesterol 7 alpha-hydroxylase (CYP7A1) Activity in Healthy Subjects

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7081" target="_blank" >RIV/00216208:11110/10:7081 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/10:7081

Result on the web

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DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Regulation of Diurnal Variation of Cholesterol 7 alpha-hydroxylase (CYP7A1) Activity in Healthy Subjects

Original language description

To better understand the regulation of CYP7A1 activity, three day-long examinations were carried out in 12 healthy men. The concentrations of 7 alpha-hydroxycholest-4-en-3-one (C4), a surrogate marker of CYP7A1 activity, bile acids (BA), insulin, glucose, nonesterified fatty acids, triglycerides, and cholesterol were measured in serum in 90-min intervals from 7 AM till 10 PM. To lower and to increase CYP7A1 activity, the investigations were also performed after cholestyramine or chenodeoxycholic acid administration. Area under the curve of C4 correlated positively with that of insulin.Our results suggest that insulin is involved in the regulation of diurnal variation of CYP7A1 activity in humans.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

ED - Physiology

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2010

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

59

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

6

Pages from-to

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UT code for WoS article

000278016200010

EID of the result in the Scopus database

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