Role of Heme Oxygenase-1 in Human Endothelial Cells Lesson From the Promoter Allelic Variants
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7181" target="_blank" >RIV/00216208:11110/10:7181 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/10:7181
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Role of Heme Oxygenase-1 in Human Endothelial Cells Lesson From the Promoter Allelic Variants
Original language description
The heme oxygenase-1(HO-1) promoter contains a (GT)n microsatellite DNA, and the number of GT repeats can influence the occurrence of cardiovascular diseases. We elucidated the effect of this polymorphism on endothelial cells isolated from newborns of different genotypes. On the basis of HO-1 expression, we classified the HO-1 promoter alleles into 3 groups: short (S) (most active), medium (moderately active), and long (least active). The presence of the S allele led to higher basal HO-1 expression andstronger induction in response to HO-1 inductors. Cells carrying the S allele survived better under oxidative stress, proliferated more efficiently and produced lower amounts of some proinflammatry mediators. The (GT)n promoter polymorphism significantlymodulates a cytoprotective, proangiogenic and antiinflammatory functions of HO-1 in human endothelium.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FA - Cardiovascular diseases including cardio-surgery
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Arteriosclerosis, Thrombosis, and Vascular Biology
ISSN
1079-5642
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
8
Country of publishing house
US - UNITED STATES
Number of pages
27
Pages from-to
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UT code for WoS article
000279886000024
EID of the result in the Scopus database
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