Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A7528" target="_blank" >RIV/00216208:11110/10:7528 - isvavai.cz</a>
Alternative codes found
RIV/00023728:_____/10:#0000091 RIV/00064165:_____/10:7528
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Histomorphometric changes by teriparatide in alendronate-pretreated women with osteoporosis
Original language description
Bone anabolic effects of teriparatide (TPTD, rhPTH (1-34) in postmenopausal women with osteoporosis may be blunted by previous exposure of bone to alendronate (ALN). Paired biopsies were obtained after tetracycline double labeling at baseline and after 24 months of TPTD treatment from 29 ALN-pretreated (64.5 +/- 16.4 months) and 16 treatment na?ve patients (TN). Biochemical markers were measured at baseline, during the treatment, or at study end. The level of increased bone formation after 24 months oftreatment with TPTD was similar in patients who were either treatment-naive or had lower bone turnover initially due to previous alendronate therapy. Elevated bone formation in postmenopausal women with osteoporosis was sustained over a 24-month period by TPTD. Biochemical markers of bone formation are a good surrogate for the assessment of TPTD effects.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FE - Other fields of internal medicine
OECD FORD branch
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Result continuities
Project
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Continuities
V - Vyzkumna aktivita podporovana z jinych verejnych zdroju
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Osteoporosis International
ISSN
0937-941X
e-ISSN
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Volume of the periodical
21
Issue of the periodical within the volume
12
Country of publishing house
GB - UNITED KINGDOM
Number of pages
10
Pages from-to
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UT code for WoS article
000285306900007
EID of the result in the Scopus database
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