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MiR-451 enhances erythroid differentiation in K562 cells

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A8657" target="_blank" >RIV/00216208:11110/10:8657 - isvavai.cz</a>

  • Alternative codes found

    RIV/00023736:_____/10:00008678

  • Result on the web

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    MiR-451 enhances erythroid differentiation in K562 cells

  • Original language description

    Erythropoiesis is a multistep process regulated at the molecular level by intrinsic and extrinsic factors including microRNAs (miRNAs). We previously identified aberrant expression of miR-451 and miR-150 in polycythemia vera erythroid differentiating cells. To address functional relevance of these miRNAs in erythroid differentiation, we employed synthetic mimics and inhibitors of miR-451 and miR-150 that we transfected into the erythroid differentiating K562 cells. We observed that enforced expression of miR-451 promoted erythroid differentiation, while inhibition of miR-150 reduced hemoglobinization of K562 cells. Microarray data of mRNA suggested potential targets regulated by miR-451: UBE2H, ARPP-19; and by miR-150: MAS4A3, AGA, PTPRR.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FD - Oncology and haematology

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NR9236" target="_blank" >NR9236: Endogeneous post-transcriptional regulation of gene function by miRNA</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2010

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Leukemia & Lymphoma

  • ISSN

    1042-8194

  • e-ISSN

  • Volume of the periodical

    51

  • Issue of the periodical within the volume

    4

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    8

  • Pages from-to

  • UT code for WoS article

    000277121400018

  • EID of the result in the Scopus database