MiR-451 enhances erythroid differentiation in K562 cells

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F10%3A8657" target="_blank" >RIV/00216208:11110/10:8657 - isvavai.cz</a>
Alternative codes found
RIV/00023736:_____/10:00008678
Result on the web
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DOI - Digital Object Identifier
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Result language
angličtina
Original language name
MiR-451 enhances erythroid differentiation in K562 cells
Original language description
Erythropoiesis is a multistep process regulated at the molecular level by intrinsic and extrinsic factors including microRNAs (miRNAs). We previously identified aberrant expression of miR-451 and miR-150 in polycythemia vera erythroid differentiating cells. To address functional relevance of these miRNAs in erythroid differentiation, we employed synthetic mimics and inhibitors of miR-451 and miR-150 that we transfected into the erythroid differentiating K562 cells. We observed that enforced expression of miR-451 promoted erythroid differentiation, while inhibition of miR-150 reduced hemoglobinization of K562 cells. Microarray data of mRNA suggested potential targets regulated by miR-451: UBE2H, ARPP-19; and by miR-150: MAS4A3, AGA, PTPRR.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FD - Oncology and haematology
OECD FORD branch
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Project
<a href="/en/project/NR9236" target="_blank" >NR9236: Endogeneous post-transcriptional regulation of gene function by miRNA</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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