The steroid metabolome in lamotrigine-treated women with epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10465" target="_blank" >RIV/00216208:11110/11:10465 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/11:7153 RIV/00023761:_____/11:#0000176 RIV/00064203:_____/11:7153 RIV/00064190:_____/11:#0000268 RIV/00064165:_____/11:10465
Result on the web
<a href="http://dx.doi.org/10.1016/j.steroids.2011.07.002" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2011.07.002</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
The steroid metabolome in lamotrigine-treated women with epilepsy
Original language description
Background: Epilepsy in women may be associated with reproductive disorders and alterations in serum steroid levels. Some steroids can be induced by epilepsy and/or treatment with antiepileptic drugs; however, there are still limited data available concerning this effect on the levels of other neuroactive steroid metabolites such as 3a-hydroxy-5a/b-reduced androstanes. Aim: To evaluate steroid alterations in women with epilepsy (WINE) on lamotrigine monotherapy. Subjects and methods: Eleven WWE and 11 age-matched healthy women underwent blood sampling in both phases of their menstrual cycles (MCs). The steroid metabolome, which included 30 unconjugated steroids, 17 steroid polar conjugates, gonadotropins, and sex hormone-binding globulin (SHBG), was measured using gas chromatography-mass spectrometry (GC-MS) and radioimmunoassay (RIA). Results: WWE had lower cortisol levels (status p < 0.001), but elevated levels of unconjugated 17-hydroxypregnenolone (status p < 0.001). Progesterone w
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
<a href="/en/project/NS9790" target="_blank" >NS9790: Neuroactive steroids in diagnostics of postpartum mental disorders</a><br>
Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Steroids
ISSN
0039-128X
e-ISSN
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Volume of the periodical
76
Issue of the periodical within the volume
12
Country of publishing house
US - UNITED STATES
Number of pages
7
Pages from-to
1351-1357
UT code for WoS article
000295745500017
EID of the result in the Scopus database
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