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The steroid metabolome in lamotrigine-treated women with epilepsy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10465" target="_blank" >RIV/00216208:11110/11:10465 - isvavai.cz</a>

  • Alternative codes found

    RIV/00216208:11130/11:7153 RIV/00023761:_____/11:#0000176 RIV/00064203:_____/11:7153 RIV/00064190:_____/11:#0000268 RIV/00064165:_____/11:10465

  • Result on the web

    <a href="http://dx.doi.org/10.1016/j.steroids.2011.07.002" target="_blank" >http://dx.doi.org/10.1016/j.steroids.2011.07.002</a>

  • DOI - Digital Object Identifier

Alternative languages

  • Result language

    angličtina

  • Original language name

    The steroid metabolome in lamotrigine-treated women with epilepsy

  • Original language description

    Background: Epilepsy in women may be associated with reproductive disorders and alterations in serum steroid levels. Some steroids can be induced by epilepsy and/or treatment with antiepileptic drugs; however, there are still limited data available concerning this effect on the levels of other neuroactive steroid metabolites such as 3a-hydroxy-5a/b-reduced androstanes. Aim: To evaluate steroid alterations in women with epilepsy (WINE) on lamotrigine monotherapy. Subjects and methods: Eleven WWE and 11 age-matched healthy women underwent blood sampling in both phases of their menstrual cycles (MCs). The steroid metabolome, which included 30 unconjugated steroids, 17 steroid polar conjugates, gonadotropins, and sex hormone-binding globulin (SHBG), was measured using gas chromatography-mass spectrometry (GC-MS) and radioimmunoassay (RIA). Results: WWE had lower cortisol levels (status p < 0.001), but elevated levels of unconjugated 17-hydroxypregnenolone (status p < 0.001). Progesterone w

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

  • CEP classification

    FB - Endocrinology, diabetology, metabolism, nutrition

  • OECD FORD branch

Result continuities

  • Project

    <a href="/en/project/NS9790" target="_blank" >NS9790: Neuroactive steroids in diagnostics of postpartum mental disorders</a><br>

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2011

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    Steroids

  • ISSN

    0039-128X

  • e-ISSN

  • Volume of the periodical

    76

  • Issue of the periodical within the volume

    12

  • Country of publishing house

    US - UNITED STATES

  • Number of pages

    7

  • Pages from-to

    1351-1357

  • UT code for WoS article

    000295745500017

  • EID of the result in the Scopus database