Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064203%3A_____%2F10%3A6356" target="_blank" >RIV/00064203:_____/10:6356 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11130/10:6356
Result on the web
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DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Effects of valproate and carbamazepine monotherapy on neuroactive steroids, their precursors and metabolites in adult men with epilepsy
Original language description
Only limited data is available concerning the role of unconjugated Delta(5) C19-steroids and almost no data exists regarding the neuroactive C21 and C19 3 alpha-hydroxy-5 alpha/beta-metabolites in men with epilepsy. To evaluate the alterations in serum neuroactive steroids and related substances in adult men with epilepsy on valproate and carbamazepine monotherapy, we have measured 26 unconjugated steroids, 18 steroid polar conjugates, gonadotropins and sex hormone binding globulin (SHBG) in 6 and 11 patients on valproate and carbamazepine monotherapy, respectively, and in 19 healthy adult men, using the GC-MS and immunoassays.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2010
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of Steroid Biochemistry and Molecular Biology
ISSN
0960-0760
e-ISSN
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Volume of the periodical
122
Issue of the periodical within the volume
4
Country of publishing house
GB - UNITED KINGDOM
Number of pages
14
Pages from-to
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UT code for WoS article
000283687100016
EID of the result in the Scopus database
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