Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00023752%3A_____%2F13%3A43914190" target="_blank" >RIV/00023752:_____/13:43914190 - isvavai.cz</a>
Alternative codes found
RIV/00023761:_____/13:#0000391
Result on the web
<a href="http://www.sciencedirect.com/science/article/pii/S0960076012001525" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0960076012001525</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jsbmb.2012.08.009" target="_blank" >10.1016/j.jsbmb.2012.08.009</a>

Result language
angličtina
Original language name
Determination of steroid metabolome as a possible tool for laboratory diagnosis of schizophrenia
Original language description
Metabolomic studies represent a promising tool for early diagnosis of schizophrenia. The aim of this study was to find differences in the steroid spectrum in patients and controls, and to assess the diagnosis of schizophrenia by building a predictive model based on steroid data. Thirty-nine serum steroids (22 neuroactive steroids and their metabolites and 17 polar conjugates) were measured by gas chromatography-mass spectrometry in 22 drug-naive (first episode) schizophrenia patients before and after six-month treatment with atypical antipsychotics and in 47 healthy subjects. In summary the following significant differences were found: In both sexes higher levels of pregnenolone sulfate and sulfated 5 alpha- as well as 5 beta-saturated metabolites of C21-steroids in progesterone metabolic pathway were found in patients, pointing to decreased activity of sulfatase. In a few instances decreased levels of the respective 5 alpha-metabolites of C21 steroids were found in patients. As C19 st
Czech name
—
Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FB - Endocrinology, diabetology, metabolism, nutrition
OECD FORD branch
—

Project
<a href="/en/project/NT13890" target="_blank" >NT13890: The role of neuroactive steroids in etiopathogenesis of mood and anxiety disorders</a><br>
Continuities
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Publication year
2013
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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