Exploring the relationship between endogenous steroids and nausea and vomiting in pregnancy: A longitudinal prospective study

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00064211%3A_____%2F26%3AW0000028" target="_blank" >RIV/00064211:_____/26:W0000028 - isvavai.cz</a>

Result on the web

<a href="https://dx.doi.org/10.1016/j.steroids.2025.109701" target="_blank" >https://dx.doi.org/10.1016/j.steroids.2025.109701</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.steroids.2025.109701" target="_blank" >10.1016/j.steroids.2025.109701</a>

Result language

angličtina

Original language name

Exploring the relationship between endogenous steroids and nausea and vomiting in pregnancy: A longitudinal prospective study

Original language description

Nausea and vomiting in pregnancy (NVP) affect approximately 70 % of women worldwide. It is thought to have an adaptive function in the first trimester, when it protects the mother and the fetus against potential dangers from the diet. Proximate causes of NVP include hormonal changes during pregnancy. This longitudinal prospective study examined associations between various endogenous steroids and NVP. In the first and third trimester, pregnant women (N = 179) completed the Index of Nausea, Vomiting, and Retching questionnaire (92.1 % of women reported at least some symptoms of NVP in the first trimester and 37.4 % in the third trimester) and we analyzed their blood serum concentrations of 91 endogenous steroids. In the first trimester, NVP intensity was significantly positively associated with progesterone metabolites from the C21 5 alpha/beta-reduced steroid group (e.g., allopregnanolone sulfate) and with conjugated 5 alpha-androstane-3 alpha,17 beta-diol and conjugated 5 alpha androstane-3 beta,17 beta-diol. In the third trimester, we found significant negative associations between NVP and progesterone, conjugated testosterone, 7-oxo-DHEA, 5-androstene-3 beta,16 alpha,17 beta-triol sulfate, some C21 Delta 5 steroids (e.g., pregnenolone sulfate, 17-hydroxypregnenolone sulfate), and C21 5 alpha/beta-reduced steroids (such as allopregnanolone sulfate and conjugated pregnanolone). Our findings suggest that sulfated 3 alpha-hydroxy-5 alpha-steroids may contribute to NVP in early pregnancy by affecting brainstem regions involved in the vomiting reflex. In late pregnancy, higher levels of immunomodulatory androstanes and progesterone may reduce NVP severity via immune regulation and smooth muscle relaxation.

Czech name

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Czech description

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Type

J_imp - Article in a specialist periodical, which is included in the Web of Science database

CEP classification

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OECD FORD branch

10608 - Biochemistry and molecular biology

Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2026

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

STEROIDS

ISSN

0039-128X

e-ISSN

1878-5867

Volume of the periodical

225

Issue of the periodical within the volume

JAN 2026

Country of publishing house

US - UNITED STATES

Number of pages

10

Pages from-to

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UT code for WoS article

001623471300001

EID of the result in the Scopus database

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