Alterations of CHEK2 forkhead-associated domain increase the risk of Hodgkin lymphoma
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10542" target="_blank" >RIV/00216208:11110/11:10542 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11120/11:00003465 RIV/00216208:11130/11:7112 RIV/00064165:_____/11:10542
Result on the web
<a href="http://dx.doi.org/10.4149/neo_2011_05_392" target="_blank" >http://dx.doi.org/10.4149/neo_2011_05_392</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Alterations of CHEK2 forkhead-associated domain increase the risk of Hodgkin lymphoma
Original language description
Checkpoint kinase 2 gene (CHEK2) codes for an important mediator of DNA damage response pathway. Mutations in the CHEK2 gene increase the risk of several cancer types, however, their role in Hodgkin lymphoma (HL) has not been studied so far. The most frequent CHEK2 alterations (including c.470T>C; p.I157T) cluster into the forkhead-associated (FHA) domain-coding region of the CHEK2 gene. We performed mutation analysis of the CHEK2 gene segment coding for FHA domain using denaturing high-performance liquid chromatography in 298 HL patients and analyzed the impact of characterized CHEK2 gene variants on the risk of HL development and progression-free survival (PFS). The overall frequency of CHEK2 alterations was significantly higher in HL patients (17/298; 5.7%) compared to the previously analyzed non-cancer controls (19/683; 2.8%; p= 0.04). Presence of any alteration within the analyzed region of the CHEK2 gene was associated with increased risk of HL development (OR = 2.11; 95% CI = 1.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
EB - Genetics and molecular biology
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)<br>S - Specificky vyzkum na vysokych skolach
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Neoplasma
ISSN
0028-2685
e-ISSN
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Volume of the periodical
58
Issue of the periodical within the volume
5
Country of publishing house
SK - SLOVAKIA
Number of pages
4
Pages from-to
392-395
UT code for WoS article
000295309700005
EID of the result in the Scopus database
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