Reduced Progesterone Metabolites in Human Late Pregnancy

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10921" target="_blank" >RIV/00216208:11110/11:10921 - isvavai.cz</a>

Alternative codes found

RIV/00023761:_____/11:#0000173 RIV/00064165:_____/11:10921

Result on the web

<a href="http://www.biomed.cas.cz/physiolres/pdf/60/60_225.pdf" target="_blank" >http://www.biomed.cas.cz/physiolres/pdf/60/60_225.pdf</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Reduced Progesterone Metabolites in Human Late Pregnancy

Original language description

In this review, we focused on the intersection between steroid metabolomics, obstetrics and steroid neurophysiology to give a comprehensive insight into the role of sex hormones and neuroactive steroids (NAS) in the mechanism controlling pregnancy sustaining. The data in the literature including our studies show that there is a complex mechanism providing synthesis of either pregnancy sustaining or parturition provoking steroids. This mechanism includes the boosting placental synthesis of CRH with approaching parturition inducing the excessive synthesis of 3 beta-hydroxy-5-ene steroid sulfates serving primarily as precursors for placental synthesis of progestogens, estrogens and NAS. The distribution and changing activities of placental oxidoreductasesare responsible for the activation or inactivation of the aforementioned steroids, which is compartment-specific (maternal and fetal compartments) and dependent on gestational age, with a tendency to shift the production from the pregnan

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FK - Gynaecology and obstetrics

OECD FORD branch

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Project

<a href="/en/project/NS9834" target="_blank" >NS9834: Changes in the profile of steroids and their neuroactive metabolites in relation to prediction of term</a><br>

Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Physiological Research

ISSN

0862-8408

e-ISSN

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Volume of the periodical

60

Issue of the periodical within the volume

2

Country of publishing house

CZ - CZECH REPUBLIC

Number of pages

17

Pages from-to

225-241

UT code for WoS article

000291154900006

EID of the result in the Scopus database

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