Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats.

Result code in IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A10931" target="_blank" >RIV/00216208:11110/11:10931 - isvavai.cz</a>

Alternative codes found

RIV/00064165:_____/11:10931

Result on the web

<a href="http://dx.doi.org/10.4149/endo_2010_04_165" target="_blank" >http://dx.doi.org/10.4149/endo_2010_04_165</a>

DOI - Digital Object Identifier

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Result language

angličtina

Original language name

Transient anorexia, hyper-nociception and cognitive impairment in eyrly adjuvant arthritis in rats.

Original language description

Objective: Rheumatoid arthritis (RA) is associated with enhanced pro-inflammatory cytokine levels, pain, anorexia, and cognitive changes. The enhanced production of cytokines appears before the full manifestation of the disease. So far, any experimentaldata on behavioral effects of early arthritis are lacking. In the present series we describe anorexia early changes in, pain hyper-sensitivity and altered cognitive behavior during the first four days of adjuvant arthritis in rats (AA), when no clinicalsigns are yet apparent. Conclusions: Early stage of AA brings about reduced body weight, food intake, and activation of central orexigenic pathways. The observed anorexia could be ascribed to the over-expression of anorexigenic IL-1? which dominates overthe NPY orexigenic effects. On day 2 of AA higher pain sensitivity and cognitive impairment appear. All the observed change tend to recover by day 4 of the disease.

Czech name

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Czech description

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Type

J_x - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)

CEP classification

FB - Endocrinology, diabetology, metabolism, nutrition

OECD FORD branch

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Project

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Continuities

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Publication year

2011

Confidentiality

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Name of the periodical

Endocrine Regulations

ISSN

1210-0668

e-ISSN

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Volume of the periodical

44

Issue of the periodical within the volume

4

Country of publishing house

SK - SLOVAKIA

Number of pages

10

Pages from-to

164-173

UT code for WoS article

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EID of the result in the Scopus database

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