Elevated CSF-lactate is a reliable marker of mitochondrial disorders in children even after brief seizures

Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A6918" target="_blank" >RIV/00216208:11110/11:6918 - isvavai.cz</a>
Alternative codes found
RIV/00064165:_____/11:6918 RIV/00216208:11310/11:10106893
Result on the web
<a href="http://dx.doi.org/10.1016/j.ejpn.2010.10.001" target="_blank" >http://dx.doi.org/10.1016/j.ejpn.2010.10.001</a>
DOI - Digital Object Identifier
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Result language
angličtina
Original language name
Elevated CSF-lactate is a reliable marker of mitochondrial disorders in children even after brief seizures
Original language description
Increased lactate is an important biochemical marker in diagnosis of children with suspicion of mitochondrial disorders. A diagnostic dilemma may originate if analyses are performed after seizures, when the increased lactate levels may be considered to result from the seizures. To address this problem, we ascertained the diagnostic value of lactate and alanine in blood and cerebrospinal fluid in children with mitochondrial disorders, epilepsy, psychomotor retardation, meningitis and meningism. Average blood and CSF-lactate levels were significantly higher in children with mitochondrial disorders and meningitis in comparison to other groups. Short seizures do not increase the CSF lactate level.
Czech name
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Czech description
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Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FG - Paediatrics
OECD FORD branch
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Project
Result was created during the realization of more than one project. More information in the Projects tab.
Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)

Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

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