Increased Uric Acid and Glucose Concentrations in Vitreous and Serum of Patients with Diabetic Macular Oedema
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11110%2F11%3A8770" target="_blank" >RIV/00216208:11110/11:8770 - isvavai.cz</a>
Alternative codes found
RIV/00216208:11160/11:10100665 RIV/00064165:_____/11:8770
Result on the web
<a href="http://dx.doi.org/10.1159/000322994" target="_blank" >http://dx.doi.org/10.1159/000322994</a>
DOI - Digital Object Identifier
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Alternative languages
Result language
angličtina
Original language name
Increased Uric Acid and Glucose Concentrations in Vitreous and Serum of Patients with Diabetic Macular Oedema
Original language description
Background: Diabetic retinopathy (DR) is characterized by blood-retina barrier breakdown induced by local changes in the retina and systemic factors. We investigated vitreous and serum levels of glucose and uric acid (UA) in patients with DR and aimed todescribe their correlation with the grade of DR. Methods: Prospective study of 81 patients with DR and 48 non-diabetic controls. Biochemical analysis of vitreous and serum samples was performed. Results: UA and glucose concentrations in vitreous and serum were significantly higher in diabetic patients than in controls. Absolute ratios (vitreous level/serum level) of UA and glucose were higher in proliferative compared with non-proliferative DR. Conclusions: The results suggest that, apart from glucose,increased levels of UA in diabetic patients may also be involved in the pathogenesis and progression of DR.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
FF - ENT (ie. ear, nose, throat), ophthalmology, dentistry
OECD FORD branch
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Result continuities
Project
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Continuities
Z - Vyzkumny zamer (s odkazem do CEZ)
Others
Publication year
2011
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Ophthalmic Research
ISSN
0030-3747
e-ISSN
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Volume of the periodical
46
Issue of the periodical within the volume
2
Country of publishing house
CH - SWITZERLAND
Number of pages
7
Pages from-to
73-79
UT code for WoS article
000293266200003
EID of the result in the Scopus database
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