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Serum vascular endothelial growth factor is a biomolecular biomarker of severity of diabetic retinopathy

The result's identifiers

  • Result code in IS VaVaI

    <a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14110%2F19%3A00124587" target="_blank" >RIV/00216224:14110/19:00124587 - isvavai.cz</a>

  • Result on the web

    <a href="https://journalretinavitreous.biomedcentral.com/articles/10.1186/s40942-019-0179-6" target="_blank" >https://journalretinavitreous.biomedcentral.com/articles/10.1186/s40942-019-0179-6</a>

  • DOI - Digital Object Identifier

    <a href="http://dx.doi.org/10.1186/s40942-019-0179-6" target="_blank" >10.1186/s40942-019-0179-6</a>

Alternative languages

  • Result language

    angličtina

  • Original language name

    Serum vascular endothelial growth factor is a biomolecular biomarker of severity of diabetic retinopathy

  • Original language description

    BackgroundElevated serum vascular endothelial growth factor (VEGF) levels are associated with diabetic retinopathy (DR). Serum VEGF levels correlate with vitreous levels. Neuroretinal changes occur even before the appearance of vascular signs in DR. Role of VEGF as a biomarker for DR has not been assessed. Serum VEGF as a biomarker for severity of DR, was evaluated for the first time.MethodsConsecutive cases of type 2 diabetes mellitus [without DR, (no DR, n=38); non-proliferative DR, (NPDR, n=38); proliferative DR, (PDR, n=40)] and healthy controls (n=40) were included. Serum VEGF was measured using enzyme linked immunosorbent assay. Accuracy of VEGF as a biomarker for severity of retinopathy was measured using the area under the receiver operator characteristic (ROC) curve.ResultsSerum VEGF levels in controls, No DR, NPDR and PDR groups showed significant incremental trend from 138.96 +/- 63.37 pg/ml (controls) to 457.18 +/- 165.69 pg/ml (PDR) (F=48.47; p&lt;0.001). Serum VEGF levels were observed to be significantly elevated even before DR had set in clinically. ROC for serum VEGF levels was significant in discriminating between the cases and the controls and had good accuracy in discerning between subjects with and without retinopathy. The area under curve (AUC +/- SE) for discrimination was significant: (a) cases and controls (n=156): AUC=0.858 +/- 0.029, p&lt;0.001; (b) DR (NPDR+PDR) and No DR (n=116): AUC=0.791 +/- 0.044, p&lt;0.001; and (c) NPDR and PDR (n=78): AUC=0.761 +/- 0.056, p&lt;0.001, with over 90% projected sensitivity and specificity at various cut off values.Conclusion Serum VEGF level is a simple, effective laboratory investigative test in predicting the onset of DR in eyes showing no evidence of DR and serves as a reliable biomolecular biomarker for severity of DR.

  • Czech name

  • Czech description

Classification

  • Type

    J<sub>imp</sub> - Article in a specialist periodical, which is included in the Web of Science database

  • CEP classification

  • OECD FORD branch

    30212 - Surgery

Result continuities

  • Project

  • Continuities

    I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Others

  • Publication year

    2019

  • Confidentiality

    S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Data specific for result type

  • Name of the periodical

    INTERNATIONAL JOURNAL OF RETINA AND VITREOUS

  • ISSN

    2056-9920

  • e-ISSN

    2056-9920

  • Volume of the periodical

    5

  • Issue of the periodical within the volume

    1

  • Country of publishing house

    GB - UNITED KINGDOM

  • Number of pages

    6

  • Pages from-to

    1-6

  • UT code for WoS article

    000693102600023

  • EID of the result in the Scopus database

    2-s2.0-85073051045