Antimyeloperoxidase antibody is a biomarker for progression of diabetic retinopathy
The result's identifiers
Result code in IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F62157124%3A16370%2F16%3A43874484" target="_blank" >RIV/62157124:16370/16:43874484 - isvavai.cz</a>
Result on the web
<a href="http://dx.doi.org/10.1016/j.jdiacomp.2016.01.010" target="_blank" >http://dx.doi.org/10.1016/j.jdiacomp.2016.01.010</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.jdiacomp.2016.01.010" target="_blank" >10.1016/j.jdiacomp.2016.01.010</a>
Alternative languages
Result language
angličtina
Original language name
Antimyeloperoxidase antibody is a biomarker for progression of diabetic retinopathy
Original language description
Aim: To study the correlation between serum antimyeloperoxidase (MPO) antibody levels with severity of diabetic retinopathy (DR). Methods: Study subjects included 60 consecutive cases of type 2 diabetes mellitus (DM): no diabetic retinopathy (NODR, n = 20); nonproliferative DR (NPDR, n = 20); proliferative DR (PDR, n = 20) and 20 healthy controls. Best corrected visual acuity (BCVA) was measured on logMAR scale. Serum anti-MPO antibody levels were evaluated using ELISA IgG kit. Serum urea and creatinine was measured using standard protocol. Data were analysed statistically. Results: Mean serum anti-MPO antibody (RU/ml) was 16.94 +/- 4.85 in controls, 17.66 +/- 4.78 in NODR, 21.51 +/- 5.27 in NPDR and 37.27 +/- 11.92 in PDR groups. On ANOVA, significant difference in visual acuity was found among the study groups (F = 73.46, p < 0.001). Serum anti-MPO antibody was correlated significantly with decrease in visual acuity (F = 48.40, p < 0.001), increase in serum urea (F = 128.13, p < 0.001) and creatinine (F = 77.10, p < 0.001). Conclusion: Increase in serum anti-MPO antibody levels correlate with increased severity of DR. Serum anti-MPO antibody may be a noteworthy biochemical marker for progression of retinopathy from nonproliferative to proliferative stage.
Czech name
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Czech description
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Classification
Type
J<sub>x</sub> - Unclassified - Peer-reviewed scientific article (Jimp, Jsc and Jost)
CEP classification
CE - Biochemistry
OECD FORD branch
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Result continuities
Project
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Continuities
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Others
Publication year
2016
Confidentiality
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Data specific for result type
Name of the periodical
Journal of diabetes and its complications
ISSN
1056-8727
e-ISSN
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Volume of the periodical
30
Issue of the periodical within the volume
4
Country of publishing house
US - UNITED STATES
Number of pages
5
Pages from-to
700-704
UT code for WoS article
000374916200022
EID of the result in the Scopus database
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